Motif ID: RXRA_VDR{dimer}.p2

Z-value: 1.253


Transcription factors associated with RXRA_VDR{dimer}.p2:

Gene SymbolEntrez IDGene Name
VDR 7421 vitamin D (1,25- dihydroxyvitamin D3) receptor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
VDRchr12_-_482987650.161.6e-02Click!


Activity profile for motif RXRA_VDR{dimer}.p2.

activity profile for motif RXRA_VDR{dimer}.p2


Sorted Z-values histogram for motif RXRA_VDR{dimer}.p2

Sorted Z-values for motif RXRA_VDR{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RXRA_VDR{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_39899749 37.939


chr19_-_36399205 31.901 NM_001173514
NM_001173515
NM_003332
NM_198125
TYROBP



TYRO protein tyrosine kinase binding protein



chr19_-_36399120 31.204 TYROBP
TYRO protein tyrosine kinase binding protein
chr19_-_36399183 28.009 TYROBP
TYRO protein tyrosine kinase binding protein
chr2_+_230787195 18.650 NM_174899
FBXO36
F-box protein 36
chr12_-_6579754 17.854 NM_014231
NM_016830
NM_199245
VAMP1


vesicle-associated membrane protein 1 (synaptobrevin 1)


chr19_+_56186426 17.216 NM_001130072
NM_013333
EPN1

epsin 1

chr19_+_1941184 17.161 CSNK1G2
casein kinase 1, gamma 2
chr17_+_2699731 16.705 NM_001100398
NM_015085
RAP1GAP2

RAP1 GTPase activating protein 2

chr21_-_46340821 15.417 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr11_+_64863700 13.807 C11orf2
chromosome 11 open reading frame 2
chr11_+_64863711 13.725 C11orf2
chromosome 11 open reading frame 2
chr11_+_64863607 13.685 NM_013265
C11orf2
chromosome 11 open reading frame 2
chr18_-_6414900 13.598 NM_173464
L3MBTL4
l(3)mbt-like 4 (Drosophila)
chr20_+_3801164 13.247 NM_001204446
NM_001204447
NM_018347
C20orf29


chromosome 20 open reading frame 29


chr19_+_56186569 12.563 EPN1
epsin 1
chr17_+_36283959 12.428 NM_001123391
NM_032258
TBC1D3C
TBC1D3
TBC1D3F
TBC1 domain family, member 3C
TBC1 domain family, member 3
TBC1 domain family, member 3F
chr17_-_34503914 12.318 NM_001001417
TBC1D3B
TBC1D3C
TBC1D3G
TBC1 domain family, member 3B
TBC1 domain family, member 3C
TBC1 domain family, member 3G
chr17_-_36348585 12.272 NM_001123391
NM_032258
TBC1D3C
TBC1D3
TBC1D3F
TBC1 domain family, member 3C
TBC1 domain family, member 3
TBC1 domain family, member 3F
chr17_-_34756980 12.246 NM_001123392
TBC1D3C
TBC1D3G
TBC1D3
TBC1D3H
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3
TBC1 domain family, member 3H
chr14_+_105780751 12.214 NM_001100913
NM_015197
PACS2

phosphofurin acidic cluster sorting protein 2

chr19_+_56186580 12.140 EPN1
epsin 1
chr11_+_124609841 11.733 NRGN
neurogranin (protein kinase C substrate, RC3)
chr7_+_94536926 11.514 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory subunit 9A

chr17_-_34591958 11.410 NM_001001418
TBC1D3C
TBC1D3G
TBC1 domain family, member 3C
TBC1 domain family, member 3G
chr15_+_83776323 11.403 NM_001144903
NM_023003
TM6SF1

transmembrane 6 superfamily member 1

chr21_-_46340776 10.879 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr16_-_4292052 10.823 NM_001098814
SRL
sarcalumenin
chr1_-_175712669 10.799 NM_003285
TNR
tenascin R (restrictin, janusin)
chr21_-_47575472 10.230 NM_006657
NM_206965
FTCD

formiminotransferase cyclodeaminase

chr19_-_44008984 10.219 NM_198850
PHLDB3
pleckstrin homology-like domain, family B, member 3
chr6_-_91006580 10.164 NM_001170794
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr6_+_35227478 10.024 NM_003427
ZNF76
zinc finger protein 76
chr17_-_76778306 9.972 NM_004762
NM_017456
CYTH1

cytohesin 1

chr1_+_226736500 9.871 NM_001003665
C1orf95
chromosome 1 open reading frame 95
chr2_-_203735988 9.758 ICA1L
islet cell autoantigen 1,69kDa-like
chr6_-_91006460 9.690 NM_021813
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr17_+_18380097 9.408 NM_001040078
LGALS9B
LGALS9C
lectin, galactoside-binding, soluble, 9B
lectin, galactoside-binding, soluble, 9C
chr11_-_790103 9.108 NM_016564
CEND1
cell cycle exit and neuronal differentiation 1
chr19_+_56186610 9.025 EPN1
epsin 1
chr19_-_47987475 8.925 NM_007059
KPTN
kaptin (actin binding protein)
chr17_-_56609361 8.546 SEPT4
septin 4
chr3_-_14988939 8.404 LOC100505641
uncharacterized LOC100505641
chr7_+_128577990 8.381 NM_001098629
NM_001098630
NM_001242452
IRF5


interferon regulatory factor 5


chr20_+_37590969 8.295 NM_001190809
NM_021931
DHX35

DEAH (Asp-Glu-Ala-His) box polypeptide 35

chr15_+_91428271 8.161 NM_001143783
NM_001143784
FES

feline sarcoma oncogene

chr10_+_80899458 8.038 ZMIZ1
zinc finger, MIZ-type containing 1
chr7_+_39989955 7.991 NM_003718
NM_031267
CDK13

cyclin-dependent kinase 13

chr3_-_14988976 7.917 LOC100505641
uncharacterized LOC100505641
chr14_+_95047730 7.729 NM_000624
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr4_-_36245893 7.539 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_+_238768186 7.520 NM_005855
RAMP1
receptor (G protein-coupled) activity modifying protein 1
chr4_-_5894695 7.417 NM_001014809
CRMP1
collapsin response mediator protein 1
chr11_+_1213469 7.288 MUC5AC
mucin 5AC, oligomeric mucus/gel-forming
chr19_-_12444435 6.902 NM_145276
ZNF563
zinc finger protein 563
chr11_+_66278076 6.877 NM_024649
BBS1
Bardet-Biedl syndrome 1
chr1_+_151043079 6.861 NM_144618
GABPB2
GA binding protein transcription factor, beta subunit 2
chr12_+_58013692 6.819 NM_133489
SLC26A10
solute carrier family 26, member 10
chr9_+_35605614 6.775 TESK1
testis-specific kinase 1
chr16_+_56623266 6.696 NM_005954
MT3
metallothionein 3
chr10_+_11047253 6.591 NM_001025077
CELF2
CUGBP, Elav-like family member 2
chr16_+_12070501 6.583 NM_032167
SNX29
sorting nexin 29
chr16_+_6823809 6.582 NM_001142334
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr3_-_54961961 6.489 NM_020678
LRTM1
leucine-rich repeats and transmembrane domains 1
chr11_+_36616039 6.485 NM_138787
C11orf74
chromosome 11 open reading frame 74
chr2_+_85921413 6.429 NM_006433
NM_012483
GNLY

granulysin

chr1_+_229406835 6.265 NM_004578
RAB4A
RAB4A, member RAS oncogene family
chr17_+_77893155 6.170


chr19_-_47987410 5.984 KPTN
kaptin (actin binding protein)
chr4_-_122872908 5.960 NM_001130698
TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr19_+_50270263 5.939 AP2A1
adaptor-related protein complex 2, alpha 1 subunit
chr22_+_50624267 5.831 TRABD
TraB domain containing
chr17_+_7554711 5.826 ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr12_+_113659287 5.714 TPCN1
two pore segment channel 1
chr19_-_9731883 5.667 NM_152289
ZNF561
zinc finger protein 561
chr19_+_589849 5.644 NM_001194
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr14_-_101034261 5.505 NM_001159531
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr2_+_20646831 5.432 NM_004040
RHOB
ras homolog gene family, member B
chr12_+_113659275 5.332 TPCN1
two pore segment channel 1
chr19_-_51891185 5.224 NM_001161748
NM_030657
LIM2

lens intrinsic membrane protein 2, 19kDa

chr1_-_203154304 5.190 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr7_+_128578246 5.178 NM_032643
IRF5
interferon regulatory factor 5
chr22_+_18593556 5.171 TUBA8
tubulin, alpha 8
chrX_+_153686620 5.163 NM_017514
PLXNA3
plexin A3
chr14_+_95047758 5.146 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr11_+_128563772 5.124 NM_001167681
NM_002017
FLI1

Friend leukemia virus integration 1

chr1_+_203764802 5.012 ZC3H11A
zinc finger CCCH-type containing 11A
chr11_-_111383063 4.992 NM_017589
BTG4
B-cell translocation gene 4
chr19_+_45409003 4.951 NM_000041
APOE
apolipoprotein E
chr16_+_19078916 4.926 NM_016138
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr3_+_13521714 4.867 NM_024827
NM_001136041
HDAC11

histone deacetylase 11

chr12_+_113659216 4.784 NM_001143819
NM_017901
TPCN1

two pore segment channel 1

chr19_-_460995 4.768 NM_012435
SHC2
SHC (Src homology 2 domain containing) transforming protein 2
chr20_+_42875943 4.736 GDAP1L1
ganglioside-induced differentiation-associated protein 1-like 1
chr20_+_42875905 4.723 NM_024034
GDAP1L1
ganglioside-induced differentiation-associated protein 1-like 1
chr17_-_42992852 4.720 NM_001131019
NM_001242376
NM_002055
GFAP


glial fibrillary acidic protein


chr3_-_149470254 4.669 NM_016094
COMMD2
COMM domain containing 2
chr4_-_170533536 4.668 NEK1
NIMA (never in mitosis gene a)-related kinase 1
chr17_-_20370819 4.648 NM_001042685
LGALS9B
lectin, galactoside-binding, soluble, 9B
chr10_+_111767877 4.637 ADD3
adducin 3 (gamma)
chr1_-_183559669 4.627 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr19_+_42259397 4.625 NM_002483
CEACAM6
carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
chr11_-_117102810 4.527 NM_004716
PCSK7
proprotein convertase subtilisin/kexin type 7
chr8_-_23540401 4.522 NM_006167
NKX3-1
NK3 homeobox 1
chr2_+_233498206 4.463 NM_025202
EFHD1
EF-hand domain family, member D1
chr1_+_44412418 4.457 NM_014652
IPO13
importin 13
chr22_+_45705965 4.442 FAM118A
family with sequence similarity 118, member A
chr22_+_45705766 4.434 NM_017911
FAM118A
family with sequence similarity 118, member A
chr11_+_46639112 4.390 ATG13
ATG13 autophagy related 13 homolog (S. cerevisiae)
chr5_-_180237114 4.368 NM_001114617
MGAT1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr1_+_100111430 4.289 NM_017734
PALMD
palmdelphin
chr1_+_22963097 4.268 NM_015991
C1QA
complement component 1, q subcomponent, A chain
chr3_+_184032414 4.164 EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr1_-_202129118 4.118 NM_080588
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr3_-_42307661 4.111 NM_000729
CCK
cholecystokinin
chr19_-_2783225 4.093 SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr22_-_29784430 4.067 AP1B1
adaptor-related protein complex 1, beta 1 subunit
chr17_+_72462780 4.061 CD300A
CD300a molecule
chr6_+_39760148 4.048 NM_001201427
DAAM2
dishevelled associated activator of morphogenesis 2
chr12_+_57610577 4.046 NM_007224
NXPH4
neurexophilin 4
chr10_+_104503724 4.025 NM_001083913
C10orf26
chromosome 10 open reading frame 26
chr9_+_34458810 3.969 NM_012144
DNAI1
dynein, axonemal, intermediate chain 1
chr19_-_2783313 3.955 SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr20_-_39946119 3.940 ZHX3
zinc fingers and homeoboxes 3
chr19_-_3869012 3.843 NM_001145640
NM_015174
ZFR2

zinc finger RNA binding protein 2

chr19_+_41620336 3.837 NM_000774
CYP2F1
cytochrome P450, family 2, subfamily F, polypeptide 1
chr22_+_23134980 3.822


chr1_-_40157067 3.820 NM_016257
HPCAL4
hippocalcin like 4
chr20_-_34195409 3.814 FER1L4
fer-1-like 4 (C. elegans) pseudogene
chr11_-_66084501 3.812 NM_020404
CD248
CD248 molecule, endosialin
chr5_-_63257959 3.805 HTR1A
5-hydroxytryptamine (serotonin) receptor 1A
chr16_-_4466595 3.796 CORO7
coronin 7
chr21_+_40177847 3.763 NM_005239
ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chrX_+_46940235 3.720 RGN
regucalcin (senescence marker protein-30)
chr10_-_22292362 3.593 DNAJC1
DnaJ (Hsp40) homolog, subfamily C, member 1
chr11_-_124806302 3.554 NM_152722
HEPACAM
hepatic and glial cell adhesion molecule
chr6_-_167040700 3.507 NM_021135
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr11_+_76883823 3.446 MYO7A
myosin VIIA
chr3_+_14989076 3.376 NM_003298
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr13_-_27334777 3.358 NM_005288
GPR12
G protein-coupled receptor 12
chr1_+_44412582 3.350 IPO13
importin 13
chr14_+_94640648 3.281 NM_020958
NM_058237
PPP4R4

protein phosphatase 4, regulatory subunit 4

chr1_+_44412640 3.244 IPO13
importin 13
chr4_+_16228273 3.244 FLJ39653
uncharacterized FLJ39653
chr22_-_19512859 3.243 NM_001130861
NM_003277
CLDN5

claudin 5

chr14_-_34419957 3.243 NM_022073
EGLN3
egl nine homolog 3 (C. elegans)
chr16_+_19078958 3.231 COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr11_-_64527369 3.217 PYGM
phosphorylase, glycogen, muscle
chr21_+_45875368 3.206 NM_030891
LRRC3
leucine rich repeat containing 3
chr19_-_46318432 3.169 NM_030785
RSPH6A
radial spoke head 6 homolog A (Chlamydomonas)
chr11_+_63997752 3.167 NM_005528
DNAJC4
DnaJ (Hsp40) homolog, subfamily C, member 4
chr20_+_42875913 3.166 GDAP1L1
ganglioside-induced differentiation-associated protein 1-like 1
chr11_-_117102758 3.128 PCSK7
proprotein convertase subtilisin/kexin type 7
chr13_-_53313835 3.114 LECT1
leukocyte cell derived chemotaxin 1
chr16_-_4466607 3.084 CORO7
coronin 7
chr17_-_43487747 3.070 ARHGAP27
Rho GTPase activating protein 27
chr2_+_74740585 3.062 TLX2
T-cell leukemia homeobox 2
chr1_-_20250051 3.047 NM_014589
PLA2G2E
phospholipase A2, group IIE
chr11_-_124805896 3.045 HEPACAM
hepatic and glial cell adhesion molecule
chr3_-_15374082 3.038 NM_004844
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr8_-_93115453 3.018 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr22_+_50624353 3.017 NM_025204
TRABD
TraB domain containing
chr11_-_6440631 2.988 NM_145689
APBB1
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
chr19_+_1941157 2.957 NM_001319
CSNK1G2
casein kinase 1, gamma 2
chr5_+_133861685 2.936 NM_015288
PHF15
PHD finger protein 15
chrX_+_153770458 2.912 NM_001099856
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr16_+_28986024 2.903 NM_001142448
NM_001142449
NM_001142450
NM_001142451
NM_032038
SPIN1
SPNS1




spindlin 1
spinster homolog 1 (Drosophila)




chr11_-_45939568 2.899 NM_004813
NM_057174
PEX16

peroxisomal biogenesis factor 16

chr7_+_39990108 2.876 CDK13
cyclin-dependent kinase 13
chr16_-_31105922 2.874


chr2_-_176866925 2.872 NM_030650
KIAA1715
KIAA1715
chr17_-_7123368 2.864 NM_001365
DLG4
discs, large homolog 4 (Drosophila)
chr19_+_38042275 2.860 NM_152606
LOC100507433
ZNF540
uncharacterized LOC100507433
zinc finger protein 540
chr19_-_54804172 2.846 NM_001172654
NM_006865
LILRA3

LILRA6
leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
chr6_-_31080331 2.812 NM_014070
C6orf15
chromosome 6 open reading frame 15
chr5_-_63257545 2.791 NM_000524
HTR1A
5-hydroxytryptamine (serotonin) receptor 1A
chr18_-_32924417 2.781 NM_006965
ZNF24
zinc finger protein 24
chr20_+_42875958 2.773 GDAP1L1
ganglioside-induced differentiation-associated protein 1-like 1
chr3_+_52529370 2.771 STAB1
stabilin 1
chr10_+_115939018 2.763 NM_198795
TDRD1
tudor domain containing 1
chr19_+_58978637 2.733 ZNF324
zinc finger protein 324
chr1_-_202129705 2.679 PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr14_-_106494166 2.656 IGHV4-31
IGHA1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
chr14_+_95047792 2.626 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr14_-_35873823 2.622 NM_020529
NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr15_-_89764809 2.619 NM_000326
RLBP1
retinaldehyde binding protein 1
chr17_+_47653474 2.618 NXPH3
neurexophilin 3
chr11_+_28129797 2.616 NM_001113528
NM_152636
METTL15

methyltransferase like 15

chr16_-_89768094 2.601 NM_152339
SPATA2L
spermatogenesis associated 2-like
chr4_+_2794811 2.563 SH3BP2
SH3-domain binding protein 2
chr1_+_175036993 2.534 NM_022093
TNN
tenascin N
chr10_+_11060105 2.534 CELF2
CUGBP, Elav-like family member 2
chr21_-_44299605 2.520 WDR4
WD repeat domain 4
chr17_+_65373574 2.510 PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr17_-_33905556 2.490 NM_000286
PEX12
peroxisomal biogenesis factor 12
chr17_-_4046190 2.481


chr11_-_60719116 2.477 NM_016582
SLC15A3
solute carrier family 15, member 3
chr5_-_39270708 2.474 NM_001243093
FYB
FYN binding protein
chr19_+_41305041 2.468 NM_080732
EGLN2
egl nine homolog 2 (C. elegans)
chr1_+_200993041 2.442



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.71 6.83e-04 GO:0032989 cellular component morphogenesis
1.32 7.50e-04 GO:0065007 biological regulation
1.33 1.08e-03 GO:0050789 regulation of biological process
1.20 1.28e-03 GO:0009987 cellular process
2.99 2.59e-03 GO:0048667 cell morphogenesis involved in neuron differentiation
2.81 3.07e-03 GO:0032990 cell part morphogenesis
2.77 6.02e-03 GO:0031175 neuron projection development
2.58 6.34e-03 GO:0000902 cell morphogenesis
2.50 7.83e-03 GO:0030030 cell projection organization
2.73 8.19e-03 GO:0048858 cell projection morphogenesis
2.82 1.14e-02 GO:0048812 neuron projection morphogenesis
2.84 1.56e-02 GO:0007409 axonogenesis
2.63 2.21e-02 GO:0000904 cell morphogenesis involved in differentiation
3.05 2.34e-02 GO:0009894 regulation of catabolic process
2.49 2.60e-02 GO:0048666 neuron development
3.94 3.62e-02 GO:0030811 regulation of nucleotide catabolic process
3.94 3.62e-02 GO:0033121 regulation of purine nucleotide catabolic process
1.29 3.85e-02 GO:0050794 regulation of cellular process
1.71 4.35e-02 GO:0048583 regulation of response to stimulus

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
8.69 4.29e-03 GO:0003823 antigen binding
6.82 2.20e-02 GO:0005097 Rab GTPase activator activity